Sytl2^tm1Mitf
Targeted Allele Detail

Summary

• Symbol: Sytl2^tm1Mitf
• Name: synaptotagmin-like 2; targeted mutation 1, Mitsunori Fukuda
• MGI ID: MGI:3693881
• Synonyms: Slp2-a^-
• Gene: Sytl2 Location: Chr7:89951460-90059927 bp, + strand Genetic Position: Chr7, 50.54 cM
• Alliance: Sytl2^tm1Mitf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116278
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the entire protein-coding region in exon 1. Western blot confirmed absence of protein in mutant stomachs. (J:116278)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Sytl2 Mutation: 62 strains or lines available

References

• Original: J:116278 Saegusa C, et al., Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells. Genes Cells. 2006 Jun;11(6):623-31
• All: 1 reference(s)