App^tm1Tsuz
Targeted Allele Detail

Summary

• Symbol: App^tm1Tsuz
• Name: amyloid beta precursor protein; targeted mutation 1, Toshiharu Suzuki
• MGI ID: MGI:3693885
• Synonyms: Aicda^tm1Tsuz
• Gene: App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
• Alliance: App^tm1Tsuz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116283
• Parent Cell Line: MS12 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A point mutation was inserted that caused a threonine to alanine mutation in codon 668 (T668A) of the intracellular domain fragment (AICD). Western blot analysis was used to confirm the absence of the wild-type threonine 668 phosphorylated protein. (J:116283, J:129354)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any App Mutation: 105 strains or lines available

References

• Original: J:116283 Nakaya T, et al., Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD. Genes Cells. 2006 Jun;11(6):633-45
• All: 3 reference(s)