Ranbp2^{Gt(pGT0pfs)630Wcs}
Gene trapped Allele Detail

Summary

• Symbol: Ranbp2^{Gt(pGT0pfs)630Wcs}
• Name: RAN binding protein 2; gene trap 630, William C Skarnes
• MGI ID: MGI:3693886
• Synonyms: Ranbp2^-
• Gene: Ranbp2 Location: Chr10:58282674-58329977 bp, + strand Genetic Position: Chr10, 29.34 cM
• Alliance: Ranbp2^{Gt(pGT0pfs)630Wcs} page

Mutation origin

• Mutant Cell Line: XB812
• Germline Transmission: Earliest citation of germline transmission: J:116134
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0pfs Vector Type: gene trap
• Mutation details: A gene trap vector containing a promoterless neo-lacZ fusion gene with a splice acceptor site at the 5' end followed by an IRES and the PLAP cassette was inserted into the locus. (J:116134)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XB812	CC156231 ; (MGI Seq Detail)	5' RACE	Chr10:58282686-58282870 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  13 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ranbp2 Mutation: 115 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:116134 Aslanukov A, et al., RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism. PLoS Genet. 2006 Oct;2(10):e177
• All: 9 reference(s)