Lyl1^tm1Fsky
Targeted Allele Detail

Summary

• Symbol: Lyl1^tm1Fsky
• Name: lymphoblastomic leukemia 1; targeted mutation 1, Fred Sablitzky
• MGI ID: MGI:3693950
• Synonyms: Lyl-1^-, Lyl-1^LacZ, Lyl1^tm1Vchr
• Gene: Lyl1 Location: Chr8:85428078-85431569 bp, + strand Genetic Position: Chr8, 41.02 cM
• Alliance: Lyl1^tm1Fsky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116300
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A lacZ-neo cassette was inserted in frame into exon 4, deleting the entire 3' end including sequences encoding the HLH domain. (J:116300)

Schematic comparison of the two targeted Lyl1^tm1Mago and Lyl1^tm1Fsky alleles

Expression

In Mice Carrying this Mutation:

5 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lyl1 Mutation: 10 strains or lines available

References

• Original: J:116300 Capron C, et al., The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation. Blood. 2006 Jun 15;107(12):4678-86
• All: 14 reference(s)