Ppargc1a^tm2Brsp
Targeted Allele Detail

Summary

• Symbol: Ppargc1a^tm2Brsp
• Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; targeted mutation 2, Bruce M Spiegelman
• MGI ID: MGI:3693963
• Synonyms: PGC-1alpha^fl
• Gene: Ppargc1a Location: Chr5:51611592-51725068 bp, - strand Genetic Position: Chr5, 27.02 cM, cytoband C1
• Alliance: Ppargc1a^tm2Brsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93896
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: This allele is the parent of Ppargc1a^tm1Brsp in which exons 3-5 were flanked by loxP sites. A neo with a third loxP site was located downstream of the floxed exons. (J:93896)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppargc1a Mutation: 48 strains or lines available

References

• Original: J:93896 Lin J, et al., Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 2004 Oct 1;119(1):121-35
• All: 50 reference(s)