Arc^tm1Stl
Targeted Allele Detail

Summary

• Symbol: Arc^tm1Stl
• Name: activity regulated cytoskeletal-associated protein; targeted mutation 1, Susumu Tonegawa
• MGI ID: MGI:3694120
• Synonyms: Arc-d2EGFP, Arc-GFP
• Gene: Arc Location: Chr15:74540932-74544419 bp, - strand Genetic Position: Chr15, 34.25 cM
• Alliance: Arc^tm1Stl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115255
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a d2EGFP-stop cassette and a floxed neo after the ATG start codon. Western blot confirmed absence of protein in mutant brain samples. (J:115255)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arc Mutation: 29 strains or lines available

References

• Original: J:115255 Wang KH, et al., In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortex. Cell. 2006 Jul 28;126(2):389-402
• All: 26 reference(s)