Igh-J^{tm1(Ighel)Cys}
Targeted Allele Detail

Summary

• Symbol: Igh-J^{tm1(Ighel)Cys}
• Name: immunoglobulin heavy chain, joining region; targeted mutation 1, Jason G Cyster
• MGI ID: MGI:3694212
• Gene: Igh-J Location: unknown Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116662
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• The VDJ segment of the HEL-specific antibody was inserted to replace JH segments 1-4. (J:116662)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh-J Mutation: 13 strains or lines available

References

• Original: J:116662 Pape KA, et al., Visualization of the genesis and fate of isotype-switched B cells during a primary immune response. J Exp Med. 2003 Jun 16;197(12):1677-87
• All: 5 reference(s)