Nasp^tm1Mgor
Targeted Allele Detail

Summary

• Symbol: Nasp^tm1Mgor
• Name: nuclear autoantigenic sperm protein (histone-binding); targeted mutation 1, Michael G O'Rand
• MGI ID: MGI:3694795
• Synonyms: Nasp^-
• Gene: Nasp Location: Chr4:116458249-116485138 bp, - strand Genetic Position: Chr4, 53.24 cM, cytoband D1
• Alliance: Nasp^tm1Mgor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116454
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Six exons were removed from the locus, resulting in the loss of amino acid residues 100-605 in the tNASP sequence and amino acid residues 74-253 in the sNASP sequence. (J:116454)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nasp Mutation: 55 strains or lines available

References

• Original: J:116454 Richardson RT, et al., Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation. J Biol Chem. 2006 Jul 28;281(30):21526-34
• All: 1 reference(s)