Gfi1^{tm3(Gfib1)Tmo}
Targeted Allele Detail

Summary

• Symbol: Gfi1^{tm3(Gfib1)Tmo}
• Name: growth factor independent 1 transcription repressor; targeted mutation 3, Tarik Moroy
• MGI ID: MGI:3695403
• Synonyms: Gfi1:Gfi1b
• Gene: Gfi1 Location: Chr5:107864521-107873671 bp, - strand Genetic Position: Chr5, 52.23 cM
• Alliance: Gfi1^{tm3(Gfib1)Tmo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116870
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• The coding region was replaced with growth factor independent 1B cDNA. (J:116870)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Gfi1^tm3(Gfib1)Tmo/Gfi1^tm3(Gfib1)Tmo	involves: 129S1/Sv * 129X1/SvJ

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
behavior/neurological	√
absent pinna reflex	√
head bobbing	√
hearing/vestibular/ear	√
abnormal cochlear inner hair cell morphology	√
abnormal cochlear outer hair cell morphology	√
absent outer hair cell stereocilia	√
cochlear outer hair cell degeneration	√
increased or absent threshold for auditory brainstem response	√
deafness	√
hematopoietic system	√
hematopoietic system phenotype	N
decreased granulocyte number	√
abnormal monocyte morphology	√
immune system	√
decreased granulocyte number	√
abnormal monocyte morphology	√
nervous system	√
abnormal cochlear inner hair cell morphology	√
abnormal cochlear outer hair cell morphology	√
absent outer hair cell stereocilia	√
cochlear outer hair cell degeneration	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gfi1 Mutation: 31 strains or lines available

References

• Original: J:116870 Fiolka K, et al., Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development. EMBO Rep. 2006 Mar;7(3):326-33
• All: 1 reference(s)