Nox1^tm1Cyn
Targeted Allele Detail

Summary

• Symbol: Nox1^tm1Cyn
• Name: NADPH oxidase 1; targeted mutation 1, Chihiro Yabe-Nishimura
• MGI ID: MGI:3695407
• Gene: Nox1 Location: ChrX:132987170-133038455 bp, - strand Genetic Position: ChrX, 55.69 cM
• Alliance: Nox1^tm1Cyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116837
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3-6 were replaced with a neomycin resistance gene. Transcripts were not detected in mutants by RT-PCR analysis. (J:116837)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nox1 Mutation: 12 strains or lines available

References

• Original: J:116837 Matsuno K, et al., Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice. Circulation. 2005 Oct 25;112(17):2677-85
• All: 16 reference(s)