Notch2^tm1Frad
Targeted Allele Detail

Summary

• Symbol: Notch2^tm1Frad
• Name: notch 2; targeted mutation 1, Freddy Radtke
• MGI ID: MGI:3695412
• Synonyms: N2^-, Notch2^flox
• Gene: Notch2 Location: Chr3:97920854-98057683 bp, + strand Genetic Position: Chr3, 42.42 cM
• Alliance: Notch2^tm1Frad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125373
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was inserted in the intron between exons c2 and d. A third loxP was inserted in the intron between exons e and f. The floxed neo was subsequently removed from one correctly targeted ES cell clone using a cre expression vector. Resulting mice have loxP sites flanking exons d and e. (J:125373)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch2 Mutation: 99 strains or lines available

References

• Original: J:125373 Besseyrias V, et al., Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation. J Exp Med. 2007 Feb 19;204(2):331-43
• All: 26 reference(s)