Ndfip1^{Gt(RRD002)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Ndfip1^{Gt(RRD002)Byg}
• Name: Nedd4 family interacting protein 1; gene trap RRD002, BayGenomics
• MGI ID: MGI:3695433
• Synonyms: Ndfip1^-
• Gene: Ndfip1 Location: Chr18:38551960-38598250 bp, + strand Genetic Position: Chr18, 20.32 cM, cytoband B3
• Alliance: Ndfip1^{Gt(RRD002)Byg} page

Mutation origin

• Mutant Cell Line: RRD002
• Germline Transmission: Earliest citation of germline transmission: J:116617
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: A gene trap vector was inserted into intron 2, resulting in the truncation of the transcript just beyond exon 2. (J:116617)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRD002	CC199955 ; (MGI Seq Detail)	5' RACE	Chr18:38552182-38576053 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  25 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndfip1 Mutation: 14 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:116617 Oliver PM, et al., Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity. 2006 Dec;25(6):929-40
• All: 17 reference(s)