Amdt1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Amdt1^C57BL/6J
• Name: amphetamine distance traveled 1; C57BL/6J
• MGI ID: MGI:3695450
• QTL: Amdt1 Location: unknown Genetic Position: Chr1, cM position of peak correlated region/allele: 6.5 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased amphetamine-induced locomotor activity compared to A/J. (J:108841)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:108841

Genetic loci associated with amphetamine-induced locomotor activation were mapped using 34 recombinant congenic strains (RCSs) derived from C57BL/6J and A/J. Eight to 15 animals from each RCS were injected with 5 mg/kg amphetamine solution and measured for total distance traveled in 10 minute intervals. Parental strain C57BL/6J exhibits a greater amount of amphetamine-induced locomotor activation compared to A/J. Six hundred twenty microsatellite markers were used for genetic analysis.

Significant linkage to amphetamine-induced locomotor activation mapped to 12 cM - 13 cM on mouse Chromosome 1 near D1Mit231 and D1Mit372a (P=0.001). This locus is designated Amdt1 (amphetamine distance traveled 1). Homozygosity for C57BL/6J-derived alleles at Amdt1 confers greater locomotor activation.

Highly significant linkage to amphetamine-induced locomotor activation mapped to 12 cM - 19 cM on mouse Chromosome 10 near D10Mit282, D10Mit16, D10Mit106, and D10Mit214. This locus is named Amdt2 (amphetamine distance traveled 2). C57BL/6J-derived alleles at Amdt1 confer increased locomotor activation. Potential candidate genes mapping near this regioninclude Oprm1 (8 cM), Esr1 (12 cM), and Ctgf (17 cM). Amdt2 colocalizes with a morphine preference QTL named Mop2 at 12 cMand overlaps with a fear response QTL, Lrnx8 at 16 cM.

Suggestive linkage to amphetamine-induced locomotor activity was identified at 9 cM on mouse Chromosome 9 near D9Mit90 (P=0.0355) and 50.5 cM on mouse Chromosome 20 near DXMit173 (P=0.0261). *Note- Mapping data in MGI places DXMit173 on mouse Chromosome X.*

References

• Original: J:108841 Torkamanzehi A, et al., Identification of informative strains and provisional QTL mapping of amphetamine (AMPH)-Induced locomotion in recombinant congenic strains (RCS) of mice. Behav Genet. 2006 Nov;36(6):903-13
• All: 1 reference(s)