Unc13a^tm3Bros
Targeted Allele Detail

Summary

• Symbol: Unc13a^tm3Bros
• Name: unc-13 homolog A; targeted mutation 3, Nils Brose
• MGI ID: MGI:3695486
• Synonyms: m, Munc13-1-EYFP
• Gene: Unc13a Location: Chr8:72079356-72124418 bp, - strand Genetic Position: Chr8, 34.43 cM, cytoband B3.3
• Alliance: Unc13a^tm3Bros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116766
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The STOP codon in exon 45 was replaced with EYFP cDNA in-frame. Western blot confirmed expression of the mutant protein. (J:116766)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Unc13a Mutation: 74 strains or lines available

References

• Original: J:116766 Kalla S, et al., Molecular dynamics of a presynaptic active zone protein studied in Munc13-1-enhanced yellow fluorescent protein knock-in mutant mice. J Neurosci. 2006 Dec 13;26(50):13054-66
• All: 5 reference(s)