Scn11a^tm1Wlf
Targeted Allele Detail

Summary

• Symbol: Scn11a^tm1Wlf
• Name: sodium channel, voltage-gated, type XI, alpha; targeted mutation 1, Clifford J Woolf
• MGI ID: MGI:3695487
• Synonyms: Nav1.9^-
• Gene: Scn11a Location: Chr9:119582829-119654522 bp, - strand Genetic Position: Chr9, 71.33 cM, cytoband F3-F4
• Alliance: Scn11a^tm1Wlf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116768
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ cassette with a loxP-flanked neo was inserted into the locus in exon 4, replacing most of exon 4 and all of exons 5 and 6. (J:116768)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn11a Mutation: 88 strains or lines available

References

• Original: J:116768 Amaya F, et al., The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity. J Neurosci. 2006 Dec 13;26(50):12852-60
• All: 3 reference(s)