Tg(Mt1-Crry)26Quig
Transgene Detail

Summary

• Symbol: Tg(Mt1-Crry)26Quig
• Name: transgene insertion 26, Richard J Quigg
• MGI ID: MGI:3695614
• Synonyms: Crry transgene
• Transgene: Tg(Mt1-Crry)26Quig Location: unknown
• Alliance: Tg(Mt1-Crry)26Quig page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mt1-Crry)26Quig expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cr1l (MGI:88513)

• Mutation details: The transgene consists of a cDNA encoding soluble mouse Crry under the control of the mouse MT-I promoter, the human growth hormone polyadenylation sequence, and the mouse MT gene 5' and 3' flanking regions, which serve as locus control regions to confer position-independent and copy number-dependent expression to the transgene. (J:117777)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1	Tg(Mt1-Crry)26Quig/?	involves: CD-1

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
immune system	√
abnormal inflammatory response	√
renal/urinary system	√
abnormal kidney physiology	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:117777 Quigg RJ, et al., Transgenic mice overexpressing the complement inhibitor crry as a soluble protein are protected from antibody-induced glomerular injury. J Exp Med. 1998 Oct 5;188(7):1321-31
• All: 8 reference(s)