Rspo3^tm1Okam
Targeted Allele Detail

Summary

• Symbol: Rspo3^tm1Okam
• Name: R-spondin 3; targeted mutation 1, Hitoshi Okamoto
• MGI ID: MGI:3695687
• Synonyms: Rspo3^-
• Gene: Rspo3 Location: Chr10:29329102-29411863 bp, - strand Genetic Position: Chr10, 16.64 cM, cytoband A4
• Alliance: Rspo3^tm1Okam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116978
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An nlsLacZ-neo cassette was inserted at the ATG in exon 1. RT-PCR failed to detect wild-type transcript in mutant embryos, however, in situ hybridization detected the expected expression of lacZ in mutants. (J:116978)

Expression

In Mice Carrying this Mutation:	42 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rspo3 Mutation: 13 strains or lines available

References

• Original: J:116978 Aoki M, et al., R-spondin3 is required for mouse placental development. Dev Biol. 2007 Jan 1;301(1):218-26
• All: 2 reference(s)