Otx2^{tm2(cre/ERT2)Tlam}
Targeted Allele Detail

Summary

• Symbol: Otx2^{tm2(cre/ERT2)Tlam}
• Name: orthodenticle homeobox 2; targeted mutation 2, Thomas Lamonerie
• MGI ID: MGI:3695701
• Synonyms: Otx2^CreERT2, Otx2^{tm2(cre/ESR1)Tlam}
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^{tm2(cre/ERT2)Tlam} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116888
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Otx2^{tm2(cre/ERT2)Tlam} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Otx2 (MGI:97451)

• Mutation details: A sequence encoding the tamoxifen-inducible Cre-ER^T2 and a neomycin resistance gene replaced the coding region. (J:116888)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Otx2 (mouse) Summary of all recombinase alleles driven by Otx2. Alliance mouse Otx2 gene page

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:116888 Fossat N, et al., Temporal and spatial delineation of mouse Otx2 functions by conditional self-knockout. EMBO Rep. 2006 Aug;7(8):824-30
• All: 8 reference(s)