Clec7a^tm1Gdb
Targeted Allele Detail

Summary

• Symbol: Clec7a^tm1Gdb
• Name: C-type lectin domain family 7, member a; targeted mutation 1, Gordon D Brown
• MGI ID: MGI:3695710
• Synonyms: Clec7a^-, dectin-1^-
• Gene: Clec7a Location: Chr6:129438554-129449742 bp, - strand Genetic Position: Chr6, 63.34 cM, cytoband F3
• Alliance: Clec7a^tm1Gdb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116669
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 1-3 were replaced with a neomycin resistance gene. (J:116669)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clec7a Mutation: 24 strains or lines available

References

• Original: J:116669 Taylor PR, et al., Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol. 2007 Jan;8(1):31-8
• All: 86 reference(s)