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Clec7atm1Yiw
Targeted Allele Detail
Summary
Symbol: Clec7atm1Yiw
Name: C-type lectin domain family 7, member a; targeted mutation 1, Yoichiro Iwakura
MGI ID: MGI:3695711
Synonyms: Dectin1-, Destin1-KO
Gene: Clec7a  Location: Chr6:129438554-129449742 bp, - strand  Genetic Position: Chr6, 63.34 cM, cytoband F3
Alliance: Clec7atm1Yiw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:116670
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a neomycin resistance gene. Absence of transcript was confirmed in Northern blot. (J:116670)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Clec7a Mutation:  24 strains or lines available
References
Original:  J:116670 Saijo S, et al., Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat Immunol. 2007 Jan;8(1):39-46
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory