Bcl3^tm1Rsch
Targeted Allele Detail

Summary

• Symbol: Bcl3^tm1Rsch
• Name: B cell leukemia/lymphoma 3; targeted mutation 1, Roland M Schmid
• MGI ID: MGI:3695737
• Synonyms: Bcl-3^-
• Gene: Bcl3 Location: Chr7:19542387-19556691 bp, - strand Genetic Position: Chr7, 9.95 cM
• Alliance: Bcl3^tm1Rsch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116724
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a fragment of the locus encoding the ankyrin repeat sequences 1-4. (J:116724)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl3 Mutation: 56 strains or lines available

References

• Original: J:116724 Riemann M, et al., The IkappaB protein Bcl-3 negatively regulates transcription of the IL-10 gene in macrophages. J Immunol. 2005 Sep 15;175(6):3560-8
• All: 2 reference(s)