Tg(SOD1*)125Dbo
Transgene Detail

Summary

• Symbol: Tg(SOD1*)125Dbo
• Name: transgene insertion 125, David Borschelt
• MGI ID: MGI:3695897
• Synonyms: H46R/H48Q/H63G/H120G, SOD1-Quad
• Transgene: Tg(SOD1*)125Dbo Location: unknown
• Alliance: Tg(SOD1*)125Dbo page

Transgene origin

• Strain of Origin: (C3H/HeJ x C57BL/6J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(SOD1*)125Dbo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOD1 (6647)

  Sod1	(MGI:98351)

• Mutation details: The H46R/H48Q/H63G/H120G mutation was engineered into a 12 kb fragment of human genomic DNA, encompassing the entire SOD1 gene. In addition to line 125, line 71 was also generated. (J:86421)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:86421 Wang J, et al., Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature. Hum Mol Genet. 2003 Nov 1;12(21):2753-64
• All: 4 reference(s)