Snx13^tm1.1Frq
Targeted Allele Detail

Summary

• Symbol: Snx13^tm1.1Frq
• Name: sorting nexin 13; targeted mutation 1, Marilyn G Farquhar
• MGI ID: MGI:3696045
• Synonyms: Snx13delta
• Gene: Snx13 Location: Chr12:35097191-35197479 bp, + strand Genetic Position: Chr12, 15.67 cM
• Alliance: Snx13^tm1.1Frq page

Snx13^tm1.1Frq/Snx13^tm1.1Frq embryos are smaller, show defects in neural tube closure, vasculogenesis and placental morphology

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117102
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3 was removed via cre-mediated recombination in ES cells, resulting in a frameshift mutation and a premature translation product containing only the N-terminal 42 residues. Absence of transcript was confirmed by RT-PCR of mutants. (J:117102)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snx13 Mutation: 53 strains or lines available

References

• Original: J:117102 Zheng B, et al., Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16776-81
• All: 1 reference(s)