Gfi1^tm1.1Wep
Targeted Allele Detail

Summary

• Symbol: Gfi1^tm1.1Wep
• Name: growth factor independent 1 transcription repressor; targeted mutation 1.1, William E Paul
• MGI ID: MGI:3696050
• Synonyms: Gfi1^-, Gfi1^deltaex4-5
• Gene: Gfi1 Location: Chr5:107864521-107873671 bp, - strand Genetic Position: Chr5, 52.23 cM
• Alliance: Gfi1^tm1.1Wep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117105
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 4 and 5 were removed via cre mediated recombination, resulting in a frame shift that prevented expression of exon 6. (J:117105)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfi1 Mutation: 31 strains or lines available

References

• Original: J:117105 Zhu J, et al., Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18214-9
• All: 4 reference(s)