Il10^tm2Roer
Targeted Allele Detail

Summary

• Symbol: Il10^tm2Roer
• Name: interleukin 10; targeted mutation 2, Axel Roers
• MGI ID: MGI:3696059
• Synonyms: IL-10^FL
• Gene: Il10 Location: Chr1:130947582-130952711 bp, + strand Genetic Position: Chr1, 56.89 cM
• Alliance: Il10^tm2Roer page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117122
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The insertion of loxP sites flanking exon 1 created this allele. (J:117122)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il10 Mutation: 45 strains or lines available

References

• Original: J:117122 Siewe L, et al., Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA. Eur J Immunol. 2006 Dec;36(12):3248-55
• All: 5 reference(s)