Or8a1^tm32Mom
Targeted Allele Detail

Summary

• Symbol: Or8a1^tm32Mom
• Name: olfactory receptor family 8 subfamily A member 1; targeted mutation 32, Peter Mombaerts
• MGI ID: MGI:3696077
• Synonyms: M71(Horp)-lacZ
• Gene: Or8a1 Location: Chr9:37641273-37642357 bp, - strand Genetic Position: Chr9, 20.8 cM
• Alliance: Or8a1^tm32Mom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115911
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: A 39 bp segment of the promotor, containing the homeodomain and the O/E-like binding sites, was replaced with a 17 bp segment from the Olfr155 promotor region and an IRES-taulacZ-ACNf cassette was inserted immediately following the endogenous stop codon. The ACNf cassette self-excised in the male germline leaving no neo sequence. (J:115911)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Or8a1^tm32Mom/Or8a1^tm32Mom	involves: 129P2/OlaHsd * C57BL/6J

Phenotypes:

Affected Systems	hm1
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nervous system	√
abnormal olfactory bulb morphology	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Or8a1 Mutation: 69 strains or lines available

References

• Original: J:115911 Rothman A, et al., The promoter of the mouse odorant receptor gene M71. Mol Cell Neurosci. 2005 Mar;28(3):535-46
• All: 1 reference(s)