Pde3b^tm1Yhc
Targeted Allele Detail

Summary

• Symbol: Pde3b^tm1Yhc
• Name: phosphodiesterase 3B, cGMP-inhibited; targeted mutation 1, Young Hun Choi
• MGI ID: MGI:3696665
• Synonyms: Pde3b^-
• Gene: Pde3b Location: Chr7:114014388-114137173 bp, + strand Genetic Position: Chr7, 59.46 cM
• Alliance: Pde3b^tm1Yhc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117353
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace a 600 bp part of exon 1, including the ATG, with a neomycin resistance cassette. (J:117353)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde3b Mutation: 43 strains or lines available

References

• Original: J:117353 Choi YH, et al., Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice. J Clin Invest. 2006 Dec;116(12):3240-51
• All: 10 reference(s)