Esr1^tm1Gsc
Targeted Allele Detail

Summary

• Symbol: Esr1^tm1Gsc
• Name: estrogen receptor 1 (alpha); targeted mutation 1, Gunther Schutz
• MGI ID: MGI:3696669
• Synonyms: ERalphaflox
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^tm1Gsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117231
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 was flanked by loxP sites. An frt-flanked neo inserted just downstream of the exon was subsequently removed via transient expression of Flp recombinase. (J:117231)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 68 strains or lines available

References

• Original: J:117231 Wintermantel TM, et al., Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. Neuron. 2006 Oct 19;52(2):271-80
• All: 9 reference(s)