Glra1^tm1Betz
Targeted Allele Detail

Summary

• Symbol: Glra1^tm1Betz
• Name: glycine receptor, alpha 1 subunit; targeted mutation 1, Heinrich Betz
• MGI ID: MGI:3696673
• Synonyms: Glra1(D80A)
• Gene: Glra1 Location: Chr11:55405065-55499024 bp, - strand Genetic Position: Chr11, 33.12 cM
• Alliance: Glra1^tm1Betz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117236
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• The D80A substitution was inserted into exon 4. (J:117236)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glra1 Mutation: 30 strains or lines available

References

• Original: J:117236 Hirzel K, et al., Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission. Neuron. 2006 Nov 22;52(4):679-90
• All: 1 reference(s)