Tg(APOE-ABCA1)30Ssf
Transgene Detail

Summary

• Symbol: Tg(APOE-ABCA1)30Ssf
• Name: transgene insertion 30, Silvia Santamarina-Fojo
• MGI ID: MGI:3696684
• Synonyms: ABCA1-Tg, hABCA1-A, hABCA1-Tg, hABCA1-tg 30c
• Transgene: Tg(APOE-ABCA1)30Ssf Location: unknown
• Alliance: Tg(APOE-ABCA1)30Ssf page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOE-ABCA1)30Ssf expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ABCA1 (19)

  Abca1

  (MGI:99607)

• Mutation details: The transgene consists of the human apoE promoter, the human ABCA1 cDNA, the poly(A) signal from the human apoE gene, and the hepatic and macrophage control regions of the apoE/apoC-I locus. Northern blot hybridization analysis and densitometric scanning demonstrated a four-fold increase in encoded mRNA in the liver and a three-fold increase in macrophages. The expressed protein was identified in both mouse liver and macrophage cell extracts by western blotting. (J:70494)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:70494 Vaisman BL, et al., ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice. J Clin Invest. 2001 Jul;108(2):303-9
• All: 3 reference(s)