Cdh1^tm4(Cdh2)Kem
Targeted Allele Detail

Summary

• Symbol: Cdh1^tm4(Cdh2)Kem
• Name: cadherin 1; targeted mutation 4, Rolf Kemler
• MGI ID: MGI:3696711
• Synonyms: Ecad^Ncad
• Gene: Cdh1 Location: Chr8:107329983-107396878 bp, + strand Genetic Position: Chr8, 53.18 cM, cytoband D
• Alliance: Cdh1^tm4(Cdh2)Kem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117056
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Sequence encoding the cadherin 2 gene was inserted into the ATG start codon, followed by a floxed neo. The neo was subsequently removed via cre-mediated recombination. (J:117056)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh1 Mutation: 173 strains or lines available

References

• Original: J:117056 Kan NG, et al., Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development. 2007 Jan;134(1):31-41
• All: 5 reference(s)