Cacng8^tm1.1Mwa
Targeted Allele Detail

Summary

• Symbol: Cacng8^tm1.1Mwa
• Name: calcium channel, voltage-dependent, gamma subunit 8; targeted mutation 1.1, Masahiko Watanabe
• MGI ID: MGI:3696717
• Synonyms: gamma-8^-, gamma-8-KO, TARP-gamma-8-deficient
• Gene: Cacng8 Location: Chr7:3442558-3464782 bp, + strand Genetic Position: Chr7, 1.98 cM
• Alliance: Cacng8^tm1.1Mwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117149
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cacng8^tm1Mwa mice were bred to Icam^tm1(cre)Mmsh mice to yield heterozygotes with the floxed region containing exon 3 of the Cacng8 gene deleted. (J:117149)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacng8 Mutation: 31 strains or lines available

References

• Original: J:117149 Fukaya M, et al., Abundant distribution of TARP gamma-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites. Eur J Neurosci. 2006 Oct;24(8):2177-90
• All: 2 reference(s)