Tg(CDX2-cre)101Erf
Transgene Detail

Summary

• Symbol: Tg(CDX2-cre)101Erf
• Name: transgene insertion 101, Eric R Fearon
• MGI ID: MGI:3696953
• Synonyms: CDX2P 9.5-NLS Cre, CDX2P9.5-NLSCre, CDX2P-NLS Cre, CPC, Tg(CDX2-cre)1Erf
• Transgene: Tg(CDX2-cre)101Erf Location: unknown
• Alliance: Tg(CDX2-cre)101Erf page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(CDX2-cre)101Erf expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  CDX2 (1045)

  Cdx2	(MGI:88361)

• Mutation details: The CDX2P9.5-NLSCre transgene was designed with a 9.5 kb promoter fragment from the 5' flanking sequences of human caudal type homeo box 2 (CDX2) gene, a Cre recombinase gene with nuclear localization signal, and a bovine growth hormone polyadenylation cassette. This transgene was injected into (C57BL/6J x SJL/J) hybrid cells. Transgenic founders (line 101) were found to have approximately 50 copies of the transgene and were bred to C57BL/6J mice. Cre expression is noted in epithelium of the ileum and cecum and throughout the colon. During early development, expression is observed throughout the caudal region of the embryo. (J:126018)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	CDX2 (human) Summary of all recombinase alleles driven by CDX2. Comparative matrix view of recombinase activities Alliance human CDX2 gene page

Disease models

Expression

In Mice Carrying this Mutation:

3 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:117412 Feng Y, et al., Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation. Cancer Res. 2007 Jan 15;67(2):482-91
• All: 44 reference(s)