Cacna1a^tm2.1Maag
Targeted Allele Detail

Summary

• Symbol: Cacna1a^tm2.1Maag
• Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; targeted mutation 2.1, Arn van den Maagdenberg
• MGI ID: MGI:3696966
• Synonyms: Cacna1a^flox
• Gene: Cacna1a Location: Chr8:85065268-85366875 bp, + strand Genetic Position: Chr8, 40.95 cM
• Alliance: Cacna1a^tm2.1Maag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117062
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele contains loxP sites flanking exon 4. A neo cassette has been removed via cre mediated recombination. Northern blot detected normal levels of RNA in these mutants. (J:117062)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1a Mutation: 118 strains or lines available

References

• Original: J:117062 Todorov B, et al., Conditional inactivation of the Cacna1a gene in transgenic mice. Genesis. 2006 Dec;44(12):589-94
• All: 16 reference(s)