Lmx1b^tm1Zfc
Targeted Allele Detail

Summary

• Symbol: Lmx1b^tm1Zfc
• Name: LIM homeobox transcription factor 1 beta; targeted mutation 1, Zhou-Feng Chen
• MGI ID: MGI:3696968
• Synonyms: Lmx1b^f, Lmx1b^flox
• Gene: Lmx1b Location: Chr2:33450977-33530620 bp, - strand Genetic Position: Chr2, 22.48 cM
• Alliance: Lmx1b^tm1Zfc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116706
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele contains loxP sites flanking exons 3-7, which contain sequence encoding the second LIM domain, the homeodomain and most of the carboxy-terminal region. (J:116706)

Disease models

Expression

In Mice Carrying this Mutation:	104108 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmx1b Mutation: 16 strains or lines available

References

• Original: J:116706 Zhao ZQ, et al., Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci. 2006 Dec 6;26(49):12781-8
• All: 32 reference(s)