Tg(Kdr-AGER)102Hyam
Transgene Detail

Summary

• Symbol: Tg(Kdr-AGER)102Hyam
• Name: transgene insertion 102, Hiroshi Yamamoto
• MGI ID: MGI:3696984
• Synonyms: RAGETg
• Transgene: Tg(Kdr-AGER)102Hyam Location: unknown
• Alliance: Tg(Kdr-AGER)102Hyam page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Kdr-AGER)102Hyam expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AGER (177)

  Ager	(MGI:893592)

• Mutation details: The mouse Kdr promoter (0.9 kb) and the 3.4 kb fragment containing the entire exonic and intronic region of the human AGER gene were ligated in the correct orientation and injected into fertilized oocytes. 6 founders were generated. Lines 102 and 103 had high expression and were used for further studies. (J:70495)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:70495 Yamamoto Y, et al., Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice. J Clin Invest. 2001 Jul;108(2):261-8
• All: 4 reference(s)