Casp8^tm1Hed
Targeted Allele Detail

Summary

• Symbol: Casp8^tm1Hed
• Name: caspase 8; targeted mutation 1, Stephen M Hedrick
• MGI ID: MGI:3696985
• Synonyms: Casp8^fl
• Gene: Casp8 Location: Chr1:58834553-58886663 bp, + strand Genetic Position: Chr1, 29.19 cM, cytoband B
• Alliance: Casp8^tm1Hed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116713
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 3 was flanked with loxP sites by homologous recombination. (J:116713)

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Casp8 Mutation: 45 strains or lines available

References

• Original: J:116713 Beisner DR, et al., Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. J Immunol. 2005 Sep 15;175(6):3469-73
• All: 52 reference(s)