Rdh12^tm1Kpal
Targeted Allele Detail

Summary

• Symbol: Rdh12^tm1Kpal
• Name: retinol dehydrogenase 12; targeted mutation 1, Krzysztof Palczewski
• MGI ID: MGI:3696994
• Synonyms: Rdh12^-
• Gene: Rdh12 Location: Chr12:79255687-79269438 bp, + strand Genetic Position: Chr12, 35.51 cM, cytoband D2
• Alliance: Rdh12^tm1Kpal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117483
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 1, 2 and 3 with a neo cassette. Immunoblot failed to detect protein in mutant retina extracts. (J:117483)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rdh12 Mutation: 17 strains or lines available

References

• Original: J:117483 Maeda A, et al., Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. J Biol Chem. 2006 Dec 8;281(49):37697-704
• All: 7 reference(s)