Char2a^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Char2a^C3H/HeJ
• Name: P. chabaudi malaria resistance QTL 2a; C3H/HeJ
• MGI ID: MGI:3697104
• QTL: Char2a Location: Chr8:71589427-90929226 bp Genetic Position: Chr8, Syntenic

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to Plasmodium chaubadi infection compared to C57BL/6J. (J:117548)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:117548

Congenic line analysis was used to refine the Char2 locus on mouse Chromosome 8. Nine recombinant congenic strains were created by repeatedly backcrossing B6.C3-Char2 to parental strain C57BL/6J. Animals from each subcongenic line were tested for malariaresistance by injection with red blood cells infected with Plasmodium chabaudi. The Char2 region appears to harbor 2 separate QTLs, designated Char2a and Char2b. Char2a is located between D8Mit27a (33 cM) and D8Mit266 (43 cM). Char2b is located between D8Mit14 (67 cM) and D8Mit56 (73 cM). C3H/HeJ-derived alleles at Char2a and Char2b appear to confer susceptibility to malaria.

References

• Original: J:117548 Lin E, et al., Mapping of the Plasmodium chabaudi resistance locus char2. Infect Immun. 2006 Oct;74(10):5814-9
• All: 1 reference(s)