Tg(Defcr2-Dta)#Jig
Transgene Detail

Summary

• Symbol: Tg(Defcr2-Dta)#Jig
• Name: transgene insertion #, Jeffrey I Gordon
• MGI ID: MGI:3697304
• Synonyms: CR2-tox176
• Transgene: Tg(Defcr2-Dta)#Jig Location: unknown
• Alliance: Tg(Defcr2-Dta)#Jig page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains the mouse Defcr2 (defensin related cryptdin 2) promoter region (-6500 to +34) and an attenuated diphtheria toxin allele with a Gly128Asp substitution. This allele has reduced potency (15-30 fold) compared to wild-type diphtheria toxin. Expression of the transgene is targeted to Paneth, granule goblet and intermediate cells of the intestine. Two lines were established but no line numbers were provided. Data for both lines were presented. (J:43025)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:43025 Garabedian EM, et al., Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice. J Biol Chem. 1997 Sep 19;272(38):23729-40
• All: 6 reference(s)