Csrp2^tm1Sfy
Targeted Allele Detail

Summary

• Symbol: Csrp2^tm1Sfy
• Name: cysteine and glycine-rich protein 2; targeted mutation 1, Shaw-Fang Yet
• MGI ID: MGI:3697317
• Synonyms: Csrp2^-
• Gene: Csrp2 Location: Chr10:110756037-110775375 bp, + strand Genetic Position: Chr10, 57.84 cM
• Alliance: Csrp2^tm1Sfy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117557
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced most of exon 3 and part of intron 3. Absence of transcript and protein was confirmed by Northern and Western blot analyses, respectively. (J:117557)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csrp2 Mutation: 95 strains or lines available

References

• Original: J:117557 Wei J, et al., Increased neointima formation in cysteine-rich protein 2-deficient mice in response to vascular injury. Circ Res. 2005 Dec 9;97(12):1323-31
• All: 3 reference(s)