Slc26a3^tm1Sole
Targeted Allele Detail

Summary

• Symbol: Slc26a3^tm1Sole
• Name: solute carrier family 26, member 3; targeted mutation 1, Manoocher Soleimani
• MGI ID: MGI:3697318
• Synonyms: dra^-
• Gene: Slc26a3 Location: Chr12:31483141-31523921 bp, + strand Genetic Position: Chr12, 13.45 cM
• Alliance: Slc26a3^tm1Sole page

Colon abnormalities in Slc26a3^tm1Sole/Slc26a3^tm1Sole mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117587
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was inserted into exon 2, 39 bp downstream of the ATG start codon. Western blot confirmed absence of protein in mutant mice. (J:117587)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc26a3 Mutation: 41 strains or lines available

Notes

ES cell line = TC1-10.

References

• Original: J:117587 Schweinfest CW, et al., slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon. J Biol Chem. 2006 Dec 8;281(49):37962-71
• All: 16 reference(s)