Tjp3^tm1Mada
Targeted Allele Detail

Summary

• Symbol: Tjp3^tm1Mada
• Name: tight junction protein 3; targeted mutation 1, Makoto Adachi
• MGI ID: MGI:3697319
• Synonyms: ZO-3
• Gene: Tjp3 Location: Chr10:81109041-81127415 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Tjp3^tm1Mada page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117589
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-21 were replaced with a lacZ-neo cassette. Absence of transcript was confirmed by RT-PCR of mutant kidney. (J:117589)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tjp3 Mutation: 35 strains or lines available

References

• Original: J:117589 Adachi M, et al., Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein. Mol Cell Biol. 2006 Dec;26(23):9003-15
• All: 1 reference(s)