Abcc4^tm1Kruh
Targeted Allele Detail

Summary

• Symbol: Abcc4^tm1Kruh
• Name: ATP-binding cassette, sub-family C member 4; targeted mutation 1, Gary D Kruh
• MGI ID: MGI:3697373
• Synonyms: Mpr4^-
• Gene: Abcc4 Location: Chr14:118720104-118943631 bp, - strand Genetic Position: Chr14, 62.24 cM
• Alliance: Abcc4^tm1Kruh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117326
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Genomic sequence encoding amino acids 77 to 101 was replaced with a neomycin resistance cassette. Absence of protein was confirmed in Western blot analysis. (J:117326)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcc4 Mutation: 153 strains or lines available

References

• Original: J:117326 Belinsky MG, et al., Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage. Cancer Res. 2007 Jan 1;67(1):262-8
• All: 1 reference(s)