G6pc3^tm1Rmob
Targeted Allele Detail

Summary

• Symbol: G6pc3^tm1Rmob
• Name: glucose 6 phosphatase, catalytic, 3; targeted mutation 1, Richard M O'Brien
• MGI ID: MGI:3697438
• Synonyms: UGRP^-
• Gene: G6pc3 Location: Chr11:102080525-102084907 bp, + strand Genetic Position: Chr11, 65.79 cM
• Alliance: G6pc3^tm1Rmob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117664
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A targeting vector was designed to replace exon 1 and 10 bp of intron 1 with a lacZ-neo cassette. (J:117664)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any G6pc3 Mutation: 12 strains or lines available

References

• Original: J:117664 Wang Y, et al., Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon. J Biol Chem. 2006 Dec 29;281(52):39982-9
• All: 2 reference(s)