Cbln3^tm1Jim
Targeted Allele Detail

Summary

• Symbol: Cbln3^tm1Jim
• Name: cerebellin 3 precursor protein; targeted mutation 1, James I Morgan
• MGI ID: MGI:3697442
• Synonyms: cbln3^-
• Gene: Cbln3 Location: Chr14:56116377-56121713 bp, - strand Genetic Position: Chr14, 28.19 cM
• Alliance: Cbln3^tm1Jim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117650
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All the coding sequence, except for the first two codons, was replaced with a lacZ-neo cassette. Successful ablation of gene expression was confirmed by Northern and Western blot analysis. (J:117650)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbln3 Mutation: 16 strains or lines available

References

• Original: J:117650 Bao D, et al., Cbln1 is essential for interaction-dependent secretion of Cbln3. Mol Cell Biol. 2006 Dec;26(24):9327-37
• All: 1 reference(s)