Hrc^tm1Blk
Targeted Allele Detail

Summary

• Symbol: Hrc^tm1Blk
• Name: histidine rich calcium binding protein; targeted mutation 1, Brian L Black
• MGI ID: MGI:3697445
• Gene: Hrc Location: Chr7:44984714-44988398 bp, + strand Genetic Position: Chr7, 29.26 cM
• Alliance: Hrc^tm1Blk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117648
• Parent Cell Line: KG-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 1. Lack of protein was confrmed by immunoblotting of mutant heart and skeletal muscle. (J:117648)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hrc Mutation: 43 strains or lines available

References

• Original: J:117648 Jaehnig EJ, et al., Increased susceptibility to isoproterenol-induced cardiac hypertrophy and impaired weight gain in mice lacking the histidine-rich calcium-binding protein. Mol Cell Biol. 2006 Dec;26(24):9315-26
• All: 1 reference(s)