Apba2^tm1Tsuz
Targeted Allele Detail

Summary

• Symbol: Apba2^tm1Tsuz
• Name: amyloid beta precursor protein binding family A member 2; targeted mutation 1, Toshiharu Suzuki
• MGI ID: MGI:3697454
• Synonyms: X11L-KO
• Gene: Apba2 Location: Chr7:64151454-64403626 bp, + strand Genetic Position: Chr7, 34.65 cM
• Alliance: Apba2^tm1Tsuz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117646
• Parent Cell Line: MS12 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced sequence containing the ATG by homologous recombination and was subsequently removed via cre-mediated recombination. Western blot failed to detect protein in mutant mice. (J:117646)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apba2 Mutation: 45 strains or lines available

References

• Original: J:117646 Sano Y, et al., Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain. J Biol Chem. 2006 Dec 8;281(49):37853-60
• All: 6 reference(s)