Camkk1^tm1Tch
Targeted Allele Detail

Summary

• Symbol: Camkk1^tm1Tch
• Name: calcium/calmodulin-dependent protein kinase kinase 1, alpha; targeted mutation 1, Talal A Chatila
• MGI ID: MGI:3697455
• Gene: Camkk1 Location: Chr11:72909834-72932899 bp, + strand Genetic Position: Chr11, 45.12 cM
• Alliance: Camkk1^tm1Tch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117630
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 2 through 5. Immunoblot confirmed absence of protein in mutants. (J:117630)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Camkk1 Mutation: 20 strains or lines available

References

• Original: J:117630 Blaeser F, et al., Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient mice. Mol Cell Biol. 2006 Dec;26(23):9105-15
• All: 4 reference(s)