Il10^tm1Mhry
Targeted Allele Detail

Summary

• Symbol: Il10^tm1Mhry
• Name: interleukin 10; targeted mutation 1, Matthias Haury
• MGI ID: MGI:3697466
• Synonyms: Il-10^eYFP, Il-10^kiki
• Gene: Il10 Location: Chr1:130947582-130952711 bp, + strand Genetic Position: Chr1, 56.89 cM
• Alliance: Il10^tm1Mhry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117628
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An eYFP was inserted into the locus in place of the first 121 nucleotides of exon 1, including the secretory signal sequence. A floxed neo was subsequently removed from the locus via cremediated excision. (J:117628)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il10 Mutation: 45 strains or lines available

References

• Original: J:117628 Calado DP, et al., Stochastic monoallelic expression of IL-10 in T cells. J Immunol. 2006 Oct 15;177(8):5358-64
• All: 1 reference(s)